BERNAL ANCHUELA, FRANCISCO JAVIER,CARRASCAL RIERA, MARTA,CATURLA JAVALOYES, JUAN FRANCISCO,GRACIA FERRER, JORDI,MATASSA, VICTOR GIULIO,TERRICABRAS BELART, EMMA,TALTAVULL MOLL, JOAN,ERRA SOLA, MONTSERR
申请号：
PE0022042013
公开号：
PE11932014A1
申请日:
2012.04.26
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Relating to compounds of formula (i) wherein: X is n or a group CR6, R6 h, halogen, Hydroxy, cyano, among others n is 0, 1, 2, or 3, ra and RB are independently h, haloalquilo c1-c4 hidroxialquilo c1-c4 alkyl, or linear or branched C1 C4 r1 is H, alkyl linear or branched C1 - C4, haloalquilo C1 - C3 - C4, C10 cycloalkyl, among others R2 and R3 are independently h, halogen, hydroxylCiano, alkoxy c1-c4, among others R4 is H, haloalquilo alkoxy C1 - C4, C1 - C4, C1 - C4 hidroxialquilo, among others R5 is (IIA), among others, where (*) represents the case in which R5 is attached to the carbon Atom attached to R4 and the Group pirrolotriazinona W1, W2 is n, among others, is, among others, R0 and R1 0 are independently h, halogen, alkoxy haloalquilo C1 - C4, C1 - C4, among others.A Preferred compound: 2 - (6 - amino - 9h purin - 9 - yl) methyl) - 5-chloro-3 - or - tolilpirrolo [1,2, - F] [1,2,4] triazin - 4 (3H) - One among others. Also referred to a Pharmaceutical composition. These compounds are inhibitors of fosfoinositido 3-kinase (PI3K), being useful for the treatment of allergic diseases, Leukemia, Type I diabetes, psoriasis, asthmaREFERIDO A COMPUESTOS DE FORMULA (I) DONDE: X ES N O UN GRUPO CR6, R6 ES H, HALOGENO, HIDROXI, CIANO ENTRE OTROS n ES 0, 1, 2, O 3 Ra Y Rb SON INDEPENDIENTEMENTE H, HALOALQUILO C1-C4, HIDROXIALQUILO C1-C4 O ALQUILO LINEAL O RAMIFICADO C1-C4 R1 ES H, ALQUILO LINEAL O RAMIFICADO C1-C4, HALOALQUILO C1-C4, CICLOALQUILO C3-C10, ENTRE OTROS R2 Y R3 SON INDEPENDIENTEMENTE H, HALOGENO, HIDROXILO, CIANO, ALCOXI C1-C4, ENTRE OTROS R4 ES H, ALCOXI C1-C4, HALOALQUILO C1-C4, HIDROXIALQUILO C1-C4, ENTRE OTROS R5 ES (IIa), ENTRE OTROS, DONDE (*) REPRESENTA EL CASO EN QUE R5 ESTA UNIDO AL ATOMO DE CARBONO UNIDO A R4 Y AL GRUPO PIRROLOTRIAZINONA, W1 ES N, ENTRE OTROS, W2 ES N, ENTRE OTROS, R9 Y R10 SON INDEPENDIENTEMENTE H, HALOGENO, ALCOXI C1-C4, HALOALQUILO C1-C4, ENTRE OTROS. UN COMPUESTO PREFERIDO ES: 2-((6-AMINO-9H-PURIN-9-IL)METIL)-5-CLORO-3-O-TOLIL
