< Topic >beshikuru outside the symbiotic bacterial origin cell inside the intestine, and the disease model which uses this, the vaccine, candidacy medicine search manner and diagnostic manner are offered.SolutionsThis invention, the symbiotic bacterium inside the intestine (gut microbiota or gut flora) regards the constituent which includes beshikuru outside the cell where it is derived, and the disease animal model which uses this. In addition, as for this invention, the infection by the symbiotic bacterium inside manner, and the intestine which search the candidacy medicine whose it is possible to prevent or to remedy the disease which is generated beshikuru outside the symbiotic bacterial origin cell inside the aforementioned intestine making use of, beshikuru outside the symbiotic bacterial origin cell inside the intestine by, efficiently or the vaccine whose it is possible to prevent and to remedy and the disease due to beshikuru outside the symbiotic bacterial origin cell inside the intestine to be efficient regards. In addition to this, beshikuru outside the symbiotic bacterial origin cell inside the intestine applying of this invention, development and the like of the technology which diagnoses the cause factor of the disease which is generated beshikuru outside the symbiotic bacterial origin cell inside the intestine by is possible.< Choice figure >Drawing 15【課題】腸内共生細菌由来細胞外ベシクル、並びにこれを用いた疾病モデル、ワクチン、候補薬物探索方法及び診断方法を提供する。【解決手段】本発明は、腸内共生細菌(gut microbiota or gut flora)に由来する細胞外ベシクルを含む組成物、及びこれを用いた疾病動物モデルに関する。また、本発明は、前記腸内共生細菌由来細胞外ベシクルを用いて、腸内共生細菌由来細胞外ベシクルにより発生する疾患を予防又は治療することが可能な候補薬物を効率よく探索する方法、及び腸内共生細菌による感染又は腸内共生細菌由来細胞外ベシクルによる疾病を効率よく予防及び治療することが可能なワクチンに関する。これに加えて、本発明の腸内共生細菌由来細胞外ベシクルを応用して、腸内共生細菌由来細胞外ベシクルにより発生する疾病の原因因子を診断する技術の開発などが可能である。【選択図】図15
