PROBLEM TO BE SOLVED: To provide a preparation capable of containing an optically hypersensitive drug stably for a long period of time.SOLUTION: This preparation of securing the optical stability is provided by spray-adding membrane-forming agent liquid or binding agent liquid obtained by blending &ge2 kinds of particle groups having different mean particle diameters, having light-shading and light-absorbing properties and having approximately &le15 &mum mean particle diameters on the surface of the optically unstable drug particles or a drug-containing granulated material to form the optical barrier layer by the coating/layering of a single layer or a plurality of layers, or by granulating.COPYRIGHT: (C)2012,JPO&INPIT【課題】光に過敏な薬物を長期間安定に含有することができる製剤を提供すること。【解決手段】光に不安定な薬物粒子もしくは薬物含有造粒物の表面に、平均粒子径の異なる二品種以上の、遮光性・吸光性を有する、平均粒子径が約15ミクロン以下の粒子群を配合した膜剤液、結合剤液をスプレー添加し、単層もしくは複数層のコーティング・レイアリングや造粒することで光バリア層を形成して、光安定性を担保した製剤を提供する。【選択図】なし
