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FORMULAÇÕES DE ANTICORPO ANTI-CD40 AQUOSAS E LIOFILIZADAS
专利权人:
NOVARTIS AG
发明人:
申请号:
PT13729089
公开号:
PT2844286T
申请日:
2013.05.02
申请国别(地区):
PT
年份:
2020
代理人:
摘要:
Anti-CD40 antibodies are formulated as lyophilisate or liquid formulation. The lyophilisates can be reconstituted to give a solution with a high concentration of the antibody active ingredient for delivery to a patient without high levels of antibody aggregation. The lyophilisate can be reconstituted with an aqueous reconstituent to provide an aqueous composition in which the antibody has a concentration of at least 50 mg/ml. The lyophilisate or aqueous pharmaceutical composition may include one or more of a sugar, a buffering agent, a surfactant, and/or a free amino acid.
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