YING, WENBIN,MINOMI, KENJIROU,HARBORTH, JENS,TAKAHASHI, HIROKAZU,TERADA, ERIKA,ZHANG, JUN,AHMADIAN, MOHAMMAD
申请号：
CA2972265
公开号：
CA2972265A1
申请日:
2015.12.28
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
This invention provides compounds, compositions and methods for modulating the expression of human GST-p using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. A nucleic acid molecule can have a) a polynucleotide sense strand and a polynucleotide antisense strand； b) each strand of the molecule being from 15 to 30 nucleotides in length； c) a contiguous region of from 15 to 30 nucleotides of the antisense strand being complementary to a sequence of an mRNA encoding GST-p； and d) at least a portion of the sense strand can be complementary to at least a portion of the antisense strand, and the molecule has a duplex region of from 15 to 30 nucleotides in length.
