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RNA agents for GST-Pi gene modulation
专利权人:
Nitto Denko Corporation
发明人:
Kenjirou Minomi,Hirokazu Takahashi,Erika Terada,Jens Harborth,Jun Zhang,Mohammad Ahmadian,Wenbin Ying
申请号:
US14979567
公开号:
US10047110B2
申请日:
2015.12.28
申请国别(地区):
US
年份:
2018
代理人:
摘要:
This invention provides compounds, compositions and methods for modulating the expression of human GST-π using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. A nucleic acid molecule can have a) a polynucleotide sense strand and a polynucleotide antisense strand; b) each strand of the molecule being from 15 to 30 nucleotides in length; c) a contiguous region of from 15 to 30 nucleotides of the antisense strand being complementary to a sequence of an mRNA encoding GST-π; and d) at least a portion of the sense strand can be complementary to at least a portion of the antisense strand, and the molecule has a duplex region of from 15 to 30 nucleotides in length.
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