JUNG, MICHAEL E.,YOO, DONGWON,SAWYERS, CHARLES L.,TRAN, CHRIS
申请号：
CA2703635
公开号：
CA2703635C
申请日:
2008.10.24
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present invention discloses diarylhydantoin compounds and methods forsynthesizing them and using them in the treatment of a hyperproliferativedisorder such ashormone refractory prostate cancer.The invention includes a compound having the formula(see formula)where R1 and R2 together can include eight or fewer carbon atoms and can beselected from thegroup consisting of alkyl, substituted alkyl, and, together with the carbon towhich they arelinked, a cycloalkyl or substituted cycloalkyl group. R3 can be hydrogen,cyano, formyl,(see formula)R4 can be hydrogen, F, CI, Br, or I. R11 and R12 can be the same or differentand are hydrogen ormethyl. R13 can be hydrogen or -NR14R15. R14 and R15 can be the same ordifferent and arehydrogen or methyl.Therefore 1-[(4-cyano-3-trifluoromethylphenyl)]-3-(4-substituted propylphenyI)-5-oxo-2-thioxoimidazolidine derivatives are disclosed and a process to make thesederivatives,pharmaceutical compositions, and the medical use of such derivatives for thetreatment ofproliferative diseases such as cancer.
