THE ASAN FOUNDATION;UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
发明人:
CHANG, EUN-JU,SONG, JAE-KWAN,KIM, MI JEONG,CHOI, BONGKUN,LEE, SAHMIN
申请号：
CA2977939
公开号：
CA2977939A1
申请日:
2015.02.27
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention relates to a composition for preventing or treating valve calcification, containing a dipeptidyl peptidase-4 (DPP-4) inhibitor. The DPP-4 inhibitor according to the present invention may include all of what can inhibit the expression of DPP-4 nucleotides or the activity of DPP-4 proteins, wherein: DPP-4 antibodies, sitagliptin, vildagliptin, saxagliptin, linagliptin, dutogliptin, gemigliptin, alogliptin, Anagliptin, evogliptin, Berberine, Diprotin, or Lupeol； DPP-4 mRNA anti-sense nucleotides, aptamers, small interfering RNA (siRNA), short hairpin RNA (shRNA), and microRNA (miRNA), or RNA interference (RNAi)； or the like can be used.
