Neil MOORCROFT;Kwon Yon MUSICK;David W. STEFANY;Sungtaek LIM;Philip M. WEINTRAUB;Shujaath MEHDI;Hartmut RUTTEN;Paul R. EASTWOOD;Stefan PEUKERT;John Z. JIANG;Uwe SCHWAHN
发明人:
Philip M. WEINTRAUB,Paul R. EASTWOOD,Shujaath MEHDI,David W. STEFANY,Kwon Yon MUSICK,Neil MOORCROFT,Sungtaek LIM,John Z. JIANG,Hartmut RUTTEN,Stefan PEUKERT,Uwe SCHWAHN
申请号：
US13449711
公开号：
US20120202795A1
申请日:
2012.04.18
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to a series of 2,3,5-substituted pyridone derivatives of formula I:wherein R, R1, R2, R3 and R4 are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5′-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.
