594405 Disclosed is an a fused heterocycle of formula (I) where the substituents are as disclosed in the specification. Examples of a compounds of formula (I) are: 3-[6-(Piperidin-1-ylcarbonyl)-1,2-benzisoxazol-3-yl]imidazo[1,2-a]pyridine-6-carbonitrile 3-[6-(Azepan-1-ylcarbonyl)-1,2-benzisoxazol-3-yl]imidazo[1,2-a]pyridine-6-carbonitrile and imidazo[1,2-a]pyridine-3-carboxylic acid [ 5-(cyclohexyl-ethyl-carbamoyl)-2-hydroxy-phenyl]-amide. Also disclosed are pharmaceutical combinations comprising a compound of formula (I) the use of a compound of formula (I) in the manufacture of a medicament. The medicament is useful in the treatment of movement disorders, acute and chronic pain, affective disorders, central and peripheric nervous system degeneration disorders, schizophrenia and related psychosis, cognitive disorders, attention disorders, central nervous system injury, cerebral ischemia, myocardial ischæmia, muscle ischæmia, sleep disorders, eye disorders, cardiovascular disorders, hepatic fibrosis, cirrhosis, fatty liver and substance abuse.
