LIEURS DE CONJUGAISON A BASE D'HETEROARYLSULFONES, LEURS PROCEDES DE PREPARATION ET LEUR UTILISATION DANS LA SYNTHESE DE CONJUGUES ANTICORPS-MEDICAMENT
DUSHIN, RUSSELL GEORGE,ABRAMITE, JOSEPH A.,CASAVANT, JEFFREY M.,CHE, YE,FILZEN, GARY FREDERICK,FLANAGAN, MARK EDWARD,GILBERT, ADAM MATTHEW,MOINE, LUDIVINE,O'DONNELL, CHRISTOPHER JOHN,ROBERTS, LEE,STAR,ODONNELL, CHRISTOPHER JOHN,STARR
申请号：
CA3032559
公开号：
CA3032559A1
申请日:
2017.07.31
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention is directed to novel heteroaryl sulfone-based conjugation handles of the formula: (wherein R1, R2, Het, D, E, X, Y, Z, m, n, p, q, r, s and t are as defined herein), methods for their preparation, their use in synthesizing antibody drig conjugates, and the resulting antibody drig conjugates made with components having heteroaryl sulfone- based conjugation handles.
