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Insulinotropic peptide synthesis
专利权人:
F. Hoffmann-La Roche AG
发明人:
Chen, Lin,Roberts, Christopher R.,Han, Yeun-Kwei
申请号:
AU2007263043
公开号:
AU2007263043B2
申请日:
2007.06.19
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
The present invention relates to the preparation of insulinotropic peptides that are synthesized using a solid and solution phase ("hybrid") approach. Generally, the approach includes synthesizing three different peptide intermediate fragments using solid phase chemistry. Solution phase chemistry is then used to add additional amino acid material to one of the fragments. The fragments are then coupled together in the solid solution phase. The use of a pseudoproline in one of the fragments eases solid phase synthesis of that fragment and also eases subsequent solution phase coupling of this fragment to other fragments. The present invention is very useful for forming insulinotropic peptides such as GLP-1(7-36) and its natural and non-natural counterparts.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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