Michael W. Stewart,Roland H. Person,Irwin J. Griffith,Paul B. Tiege,Antoine Noujiam
申请号：
US14668905
公开号：
US20160074482A1
申请日:
2015.03.25
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates generally to methods and compositions for targeting and delivering solid-phase platelet-dependent vascular occlusion agents. In particular, particles or coils or stents coated with platelet binding agents are directed to target vasculature, such as the vasculature of solid tumor masses or AV-malformations or aneurysms or endoleaks the solid-phase agent then binds and activates platelets, which in turn bind and activate other platelets. This process results in the rapid formation of a platelet-mediated thrombus about the solid-phase agent causing vessel occlusion.
