An antibody to be used in the prevention, treatment or relief of the effects of amyloidosis, a group of diseases and disorders associated with the formation of amyloid plaques which includes secondary amyloidosis and age-related amyloidosis, obtainable by method comprising generating antibodies against an antigenic peptide corresponding to the amino acid sequence of the Aβ peptide antigen consisting of a single or repetitive stretch of between 13 and 15 contiguous amino acid residues of the N-terminal part of the Aβ peptide, and modified with hydrophobic parts covalently linked to each terminal of the antigenic peptide through at least one amino acid coupled to the terminal amino acid residue at each end of the antigenic peptide and reconstituted in a liposome, wherein: a) the Aβ peptide is preformed by automated peptide synthesis resin standard and modified by graft over re-resin of a lipophilic or hydrophobic part to the terminal amino acid residues of the preformed Aβ peptide； and b) said antibody is a bifunctional antibody, which, when subjected to co-incubation with soluble β-amyloid monomeric and oligomeric peptides, inhibits the aggregation of Aβ monomers in the form of polymeric fibrils of high molecular weight, and also, during co-incubation With fibrils or filaments of high molecular weight amyloid formed by the aggregation of monomeric β-amyloid peptides, it is capable of disaggregating the preformed polymeric fibrils or filaments.Un anticuerpo para ser utilizado en la prevención, tratamiento o alivio de los efectos de la amiloidosis, un grupo de enfermedades y trastornos asociados con la formación de placas de amiloide lo que incluye la amiloidosis secundaria y la amiloidosis relacionada con la edad, obtenible mediante un método que comprende generar anticuerpos contra un péptido antigénico correspondiente a la secuencia de aminoácidos del antígeno peptídico Aß consistente en un tramo único o repetitivo de entre 13 y 15 residuos de aminoácidos contiguos
