СЮЙ Тин (US),ДУН Хэ (US),ШУ Джессика (US),ДУБ Никил (US)
申请号：
RU2014144945
公开号：
RU2014144945A
申请日:
2013.04.10
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. A conjugate comprising: a first peptide having from about 10 to about 100 amino acids, wherein the peptide assumes a helical structure, the first polymer is covalently bound to an amino acid residue of the peptide, except N-terminal and C-terminal amino acid residues, at least one second polymer is covalently bound to the C-terminal amino acid residue of the peptide igidrofobnuyu group covalently attached to the N-end peptide, wherein the hydrophobic group comprises a third polymer or lipid gruppu.2. . The conjugate of claim 1, wherein the peptide is selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 5 and SEQ ID NO: 6.3. The conjugate according to Claim. 1, wherein the first polymer and the second polymer each comprises a hydrophilic polimer.4. The conjugate according to Claim. 1, wherein the first polymer and the second polymer each comprises polietilenglikol.5. The conjugate according to Claim. 1, wherein the molecular weight of the first polymer is from about 500 Da to about 10,000 Da.6. The conjugate of claim. 5, wherein the molecular weight of the first polymer is from about 1000 Da to about 5000 Da.7. The conjugate of claim. 6, wherein the molecular weight of the first polymer is about 2,000 Da.8. The conjugate according to Claim. 1, wherein the molecular weight of the second polymer is from about 250 Da to about 5000 Da.9. A conjugate according to claim. 8, wherein the molecular weight of the second polymer is from about 500 Da to about 2000 Da.10. The conjugate of claim. 9, wherein the molecular weight of the second polymer is about 750 Da.11. The conjugate according to Claim. 1, wherein the third polymer comprises polibutadien.12. The conjugate according to Claim. 1, wherein the lipid moiety comprises from 1 to 6 C-acyl groups.13. The conjugate according to Claim. 1, wherein the lipid moiety comprises 1, 2 or 4-acyl gruppy.14. The conjugate according to Claim. 1 further comprising a second peptide covalently attac
