THE GOVERNMENT OF THE UNITED STATES OF AMERICA, RE;BARSOV, EUGENE;HUGHES, STEPHEN, H.
发明人:
BARSOV, EUGENE,HUGHES, STEPHEN, H.
申请号：
WO1996US07370
公开号：
WO9637625(A1)
申请日:
1996.05.22
申请国别(地区):
世界知识产权组织国际局
年份:
1996
代理人:
摘要：
Recombinant avian sarcoma leukosis virus (ASLV)-derived retrovirus vectors having an expanded host range are described. The host range is expanded by the replacement of the ASLV envelope gene by an envelope gene from a virus capable of infecting both mammalian and avian cells. The resulting recombinant ASLV-derived retroviral vectors can replicate efficiently in avian cells, infect both avian and mammalian cells in high titer, and are replication-defective in mammalian cells. Thus, they are quite safe and advantageous for use in gene therapy and vaccines.
