Substituted benzylindazoles for use as bub1 kinase inhibitors in the treatment of hyperproliferative diseases.

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专利权人:

BAYER INTELLECTUAL PROPERTY GMBH

发明人:

BRIEM HANS,HOLTON SIMON,PRECHTL STEFAN,SIEMEISTER GERHARD,HITCHCOCK MARION,LIENAU PHILIP,EIS KNUT,WENGNER ANTJE MARGRET,GNOTH MARK JEAN,MENGEL ANNE,PÜTTER VERA,SCHULZE VOLKER,FERNANDEZ-MONTALVAN AMAUR

申请号：

NZ62309812

公开号：

NZ623098A

申请日:

2012.10.04

申请国别(地区):

NZ

年份:

2016

代理人:

摘要：

Provided are pyrimidine substituted benzylindazoles of the general formula (I), wherein the variables are as defined in the specification. Examples of the compounds include 2-[1-(6-chloro-2-fluoro-3-methylbenzyl)-1H-indazol-3-yl]-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine and 2-[1-(4-ethoxy-2,6-difluorobenzyl)-4-methyl-1H-indazol-3-yl]-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine. The compounds are inhibitors of Bub1 kinase. The compounds may be useful in the treatment of cancer.

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