GROSSMAN, WILLIAM J.,ANTONYSAMY, MARY A.,WALSH, RICHARD M.,NELSON, MARIANA I.,BOSE, NANDITA,DANIELSON, MICHAEL E.,MICHEL, KYLE S.
申请号：
CA2872009
公开号：
CA2872009A1
申请日:
2013.03.14
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
This disclosure describes, in one aspect, a method for identifying ß-glucan binding to immune cells of a subject. Generally, the method includes obtaining a blood sample from the subject, the blood sample comprising immune cells, adding soluble ß-glucan to at least a portion of the blood sample and incubating the mixture under conditions allowing the soluble ß-glucan to bind to the immune cells, and detecting soluble ß-glucan bound to the immune cells. In another aspect, this disclosure describes a method that generally includes identifying the subject as a low binder of ß-glucan, and co-administering to the subject a soluble ß-glucan and an antibody preparation capable of converting the subject from a low binder to a high binder.
