William J. Grossman,Mary A. Antonysamy,Richard M. Walsh,Mariana I. Nelson,Nandita Bose,Michael E. Danielson,Kyle S. Michel
申请号：
US14398019
公开号：
US20150125461A1
申请日:
2013.03.14
申请国别(地区):
US
年份:
2015
代理人:
摘要：
This disclosure describes, in one aspect, a method for identifying β-glucan binding to immune cells of a subject. Generally, the method includes obtaining a blood sample from the subject, the blood sample comprising immune cells, adding soluble β-glucan to at least a portion of the blood sample and incubating the mixture under conditions allowing the soluble β-glucan to bind to the immune cells, and detecting soluble β-glucan bound to the immune cells. In another aspect, this disclosure describes a method that generally includes identifying the subject as a low binder of β-glucan, and co-administering to the subject a soluble β-glucan and an antibody preparation capable of converting the subject from a low binder to a high binder.
