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CARTILAGE GEL FOR CARTILAGE REPAIR COMPRISING CHITOSAN AND CHONDROCYTES
专利权人:
发明人:
HAZOT PASCALE,MALLEIN GERIN FRDRIC
申请号:
IN201717023050
公开号:
IN201717023050A
申请日:
2017.06.30
申请国别(地区):
IN
年份:
2018
代理人:
摘要:
The present invention relates to a process for obtaining an implantable cartilage gel for hyaline cartilage tissue repair comprising particles of hydrogel of chitosan and cells capable of forming hyaline cartilage said process comprising a step of amplification of primary cells in a three dimensional structure comprising particles of physical hydrogel of chitosan or of chitosan derivative then a step of redifferentiation and of induction of extracellular matrix synthesis by said amplified cells within the same three dimensional structure wherein said cells are primary articular chondrocytes and/or primary mesenchymal stem cells differentiated into chondrocytes. The present invention also relates to the resulting cartilage gel and to the various uses thereof for cartilage repair following a traumatic impact or an osteoarticular disease such as osteoarthrosis. The invention also relates to a three dimensional matrix comprising particles of physical hydrogel of chitosan or of chitosan derivative optionally supplemented with an anionic molecule such as hyaluronic acid or a hyaluronic acid derivative or a hyaluronic acid complex.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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