Shin, Young Key,Park, Sang Gyu,Kim, Young Deug,Ahn, Jong Chan,Park, Byoung Jun,Lee, Ui Il
申请号：
AU2016382166
公开号：
AU2016382166A1
申请日:
2016.10.01
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
The present invention is to provide a 3D cartilage organoid block prepared by differentiating mesenchymal stem cells into 3D spheroid cartilage tissues, a basic unit for the 3D cartilage spheroid block. The inventors found that both the amount of GAG matrix and the expression of the collagen type2 increased. Therefore, the method of this invention provides clinically applicable cartilage tissues by effectively enhancing the function of the cartilage differentiation constructs according to 2D culture. The 3D cartilage organoid block can be usefully applied to the area, such as, articular cartilage regeneration and plastic aurgery, where cartilage tissues restoration is required.
