COMPOSITION POUR PRÉVENIR OU TRAITER DES MALADIES INFLAMMATOIRES, COMPRENANT DES VÉSICULES EXTRACELLULAIRES DÉRIVÉES DE BACTÉRIES D'ACIDE LACTIQUE COMME PRINCIPES ACTIFS
The present invention relates to: a composition for preventing, ameliorating, or treating inflammatory diseases, the composition comprising, as active ingredients, lactic acid bacteria-derived extracellular vesicles isolated from culture fluid of lactic acid bacteria； and a method for diagnosing atopic dermatitis. It was confirmed via in vitro and in vivo experiments that the lactic acid bacteria-derived extracellular vesicles according to the present invention are significantly more distributed in the urine and blood of a patient with inflammatory diseases than a normal person, and inflammatory response in epithelial cells and inflammatory cells caused by exposure to Staphylococcus or Pseudomonas-derived extracellular vesicles is efficiently inhibited by the lactic acid bacteria-derived extracellular vesicles. Thus, the composition comprising the lactic acid bacteria-derived extracellular vesicles as active ingredients is expected to be usefully used in development of drugs, cosmetics, or health functional food for preventing, ameliorating, or treating inflammatory diseases such as atopic dermatitis, chronic rhinitis, chronic rhinosinusitis, asthma, chronic obstructive pulmonary disease, sepsis, etc. Also, the composition will be usefully used for diagnosis of atopic dermatitis by measuring the distribution of lactic acid bacteria-derived extracellular vesicles in a urine or blood sample.
