PURPOSE: a kind of composition, the antisense molecule comprising miRNA or miRNA are provided to adjustment tyrosinase mRNA expression and pigmentation and to enhance skin whitening effects.CONSTITUTION: a kind of adjusting pigmentation gene relevant with expression miRNA pigmentations includes that sequence number 1 is used as active constituent. It selects and is also selected from oligonucleotide molecules to contain 22 continuous bases and CCCUGAG in the serial number 1 of the miRNA sequence. The relevant gene of pigmentation is tyrosinase mRNA. The composition is the effective component of cosmetics or pharmaceutical composition. A kind of adjusting pigmentation gene base sequence complementary relevant with expression pigmentation, can hybrid and miRNA in the sequence number 2 of the sequence number comprising which miRNA and antisense nucleic acid molecule.The 2013 of copyright KIPO submissions[Reference numerals] (AA) expresses TYR/GAPDH with respect to mRNA (BB) compare embodiment 1 (CC) compare embodiment 2 (DD) MiR-125b derivatives
