Joan Heather Hogg;Frederick Brookfield;Xiaochun Han;Eric Brian Sjogren;Jaehyeon Park;Florence Eustache;David Michael Goldstein;Leyi Gong;Deborah Carol Reuter;Michael Patrick Dillon
发明人:
Frederick Brookfield,Florence Eustache,Michael Patrick Dillon,David Michael Goldstein,Leyi Gong,Xiaochun Han,Joan Heather Hogg,Jaehyeon Park,Deborah Carol Reuter,Eric Brian Sjogren
申请号：
US12387181
公开号：
US08268840B2
申请日:
2009.04.29
申请国别(地区):
US
年份:
2012
代理人:
摘要：
This application discloses novel pyrimidinyl pyridone derivatives according to formula I, wherein A, R1, R2, R3, and mare defined as described herein, which inhibit JNK. The compounds disclosed herein are useful to modulate the activity of JNK and treat diseases associated with excessive JNK activity. The compounds are useful to treat autoimmune, inflammatory, metabolic, and neurological diseases as well as cancer. Also disclosed are compositions comprising the compound of formula I and methods of treatment comprising administering a therapeutically effective amount of the compound of formula I to a subject in need thereof.
