Leyi Gong;Wylie Solang Palmer;Kristen Lynn McCaleb;Genevieve N. Boice
发明人:
Genevieve N. Boice,Leyi Gong,Kristen Lynn McCaleb,Wylie Solang Palmer
申请号：
US12603726
公开号：
US08404695B2
申请日:
2009.10.22
申请国别(地区):
US
年份:
2013
代理人:
摘要：
This application discloses novel pyrimidinyl pyridone derivatives according to Formula I,wherein R1, R2, and R3 are defined as described herein, which inhibit JNK. The compounds disclosed herein are useful to modulate the activity of JNK and treat diseases associated with excessive JNK activity. The compounds are useful to treat autoimmune, inflammatory, metabolic, and neurological diseases as well as cancer. Also disclosed are compositions comprising the compound of Formula I and methods of treatment comprising administering a therapeutically effective amount of the compound of Formula I to a subject in need thereof.
