BROOKFIELD FREDERICK,DILLON MICHAEL PATRICK,EUSTACHE FLORENCE,GOLDSTEIN DAVID MICHAEL,GONG LEYI,HAN XIAOCHUN,HOGG JOAN HEATHER,PARK JAEHYEON,REUTER DEBORAH CAROL,SJOGREN ERIC BRIAN
申请号：
IN7388/DELNP/2010
公开号：
IN2010DN07388A
申请日:
2010.10.20
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
This application discloses novel pyrimidinyl pyridone derivatives according to formula I, wherein A, R1, R2, R3, and m are defined as described herein, which inhibit JNK. The compounds disclosed herein are useful to modulate the activity of JNK and treat diseases associated with excessive JNK activity. The compounds are useful to treat autoimmune, inflammatory, metabolic, and neurological diseases as well as cancer. Also disclosed are compositions comprising the compound of formula I and methods of treatment comprising administering a therapeutically effective amount of the compound of formula I to a subject in need thereof.
