PURPOSE: A pharmaceutical composition and a food composition containing a tuna eye extract as an active ingredient for preventing or treating arthritis is provided to effectively suppress autoimmune diseases and inflammation which are developed in joint without side effects by inducing immunotolerance and to prevent and treat arthritis. CONSTITUTION: A pharmaceutical composition for preventing and treating arthritis contains a tuna eye crushed material or extract as an active ingredient. The composition induces immunotolerance which occurs in gut associated lymphoid tissue (GALT). The composition additionally contains glucosamine, chondroitin, or a combination thereof. A food composition for treating arthritis contains the tuna eye crushed material or extract as an active ingredient. [Reference numerals] (AA) Score； (BB) Comparative example 1-3； (CC) Comparative example 1-2； (DD) Comparative example 1-1； (EE) Example 1-3； (FF) Example 1-2； (GG) Example 1-1； (HH) Negative control group； (II) Number of elapse days본 발명은 참치 안구 파쇄물 또는 추출물을 유효성분으로 포함하는 관절염 예방 및 치료용 조성물에 관한 것으로, 장관계 면역 시스템에서 일어나는 면역관용을 유도함으로써 부작용 없이 관절에 특이적으로 일어나는 자가 면역반응 및 염증을 효과적으로 제어하여 관절염을 예방 및 치료할 수 있다.
