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DUAL SPECIFIC ANTIBODIES
专利权人:
Inc.;Genentech
发明人:
Germaine FUH,Chingwei V. LEE,Patrick KOENIG
申请号:
US15167030
公开号:
US20160257744A1
申请日:
2016.05.27
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The invention provides dual specific antibodies and methods of making and using such antibodies. In general, the dual specific antibodies are generated by identification of a monospecific antibody having light chain variable region VL residues that are electrostatic or hydrophobic and altering the nucleic acid sequence encoding one or more solvent accessible residues in the VH of the antibody either alone or in combination with alteration of the nucleic acid sequence encoding the VL of the antibody. The altered VH and the VL are expressed and dual specific antibodies, or antigen-binding fragments thereof, are selected. Exemplary dual specific antibodies are also provided as well as methods of using the antibodies.
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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