Sexton Daniel J.,Tenhoor Christopher,Viswanathan Malini
申请号：
NZ71505712
公开号：
NZ715057A
申请日:
2012.06.01
申请国别(地区):
NZ
年份:
2017
代理人:
摘要：
Disclosed is a method of producing an antibody specific to a neonatal Fc receptor (FcRn), the method comprising: (i) culturing a host cell comprising a first nucleic acid encoding a light chain variable region (VL) of the antibody, and a second nucleic acid encoding a heavy chain variable region (VH) of the antibody to produce the antibody, wherein each of the first nucleic acid and the second nucleic acid is in operable linkage to a promoter； and (ii) collecting the antibody produced in (i)； wherein: the VL comprises a VL CDR1 that comprises the amino acid sequence of TGTGSDVGSYNLVS (SEQ ID NO:14)； a VL CDR2 that comprises the amino acid sequence of GDSQRPS (SEQ ID NO:15)； and a VL CDR3 that comprises the amino acid sequence of SSYAGSGIYV (SEQ ID NO:12) or ASYAGSGIYV (SEQ ID NO:13)； and the VH comprises a VH CDR1 that comprises the amino acid sequence of EYAMG (SEQ ID NO:22)； a VH CDR2 that comprises the amino acid sequence of SIGSSGGQTKYADSVKG (SEQ ID NO:23)； and a VH CDR3 that comprises the amino acid sequence of LAIGDSY (SEQ ID NO:24).
