HILDBRAND STEFAN,KAMMERER MICHAEL,CARR ROBERT,HODGES MARK L.,LANG JOHN F.,LAWRIMORE III WILLIAM J.,NGUYEN DIEU
申请号：
NZ63118213
公开号：
NZ631182A
申请日:
2013.05.27
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed herein is a process for the preparation of (2&rsquoR)-2&rsquo-deoxy-2&rsquo-fluoro-2&rsquo-methylcytidine derivatives of formula (I), which involves a step of coupling of the silylated N-benzoyl cytosine with the (2R)-2-deoxy-2-fluoro-2-methyl-D-ribofuranosyl chloride, wherein R1 is selected from C1-4-alkyl is described. The (2&rsquoR)-2&rsquo-deoxy-2&rsquo-fluoro-2&rsquo-methylcytidine derivatives of formula (I) have the potential to be useful as prodrugs for potent inhibitors of the Hepatitis C Virus (HCV) NS5B polymerase.
