BERND BUETTELMANN,SIMONA M. CECCARELLI,HOLGER KUEHNE,BERND KUHN,WERNER NEIDHART,ULRIKE OBST SANDER,HANS RICHTER
申请号：
ARP130102125
公开号：
AR091464A1
申请日:
2013.06.17
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
It includes the second type of diabetes, carcinogenicity, cancer, steroids, compounds of chronic kidney disease and methods of using compounds. This is a Fapp 4 and / or 5 protein inhibitor Claim 1: a compound of equation (1), wherein R 1 and R 2 are added together to form un-cr1-8308；-CR R -O- (CR R) -CR R --CR R - (CR R) -O-CR R-O-CR R - (CR R) -CR R --CR R -NR -CR R -CR R --CR R -S (O) -CR R -CR R --CR¹⁴R¹⁵-CR²⁰R²¹- o -CR¹⁴R¹⁵-CR¹⁶R¹⁷-(CR¹⁸R¹⁹)ₚ-CR²⁰R²¹-；R3: is a kind of arilo which is replaced by R2: 3, or R2 8308y and / or r83099；h. R8308es h or asphalt； r83090 and r8310e are independently selected from h, asphalt and cyclopentadiene； r8311es h, asphalt or cyclopentadiene； a No. 831222 or cr8313； r183044；E is nhr1 or Cr13；R831222 and R1 were selected independently from h, asphalt and cicycladylol； r8313；R830404,R2 and R1 3 are independently selected from h, halogen, asphalt, halogen and cyclopentadiene； or r83099 and R1 form a cyclopentyl compound together with the carbon atoms connected with them, substituting, substituting, isocyclopentyl or isomerizing, substituting cyclopentyl or isomerizing, substituting cyclopentyl or non cyclopentyl. e. It can also be replaced by r.8311 and / or r.831222；However, if r83099 and R1 square together with the carbon atoms connected to them form an alternative or heterocyclic alternative arilo, r8310 and R1 3 will not exist； or r831222 and R1 square together with the nitrogen and carbon atoms connected to them will form an alternative or heterocyclic chemistry, These alternatives were replaced by r2.8310 or r2.8311 and / or r8322；However, r1.3 will not exist if r831222 and R1 square together with the carbon atoms connected with them form a heteromorphic substitute, or r8313 and R1 together with the nitrogen and carbon atoms connected with them form an isomerized substitute or an isomerized substitute, then these isomerized synthetic chlorine substitutes. e. R.8310 and / or r.831222 can be used instead of the heteromorphism；How
