EXOTOXINS OF MUTED PSEUDOMONES WITH REDUCED ANTIGENICITY.

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专利权人:

AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMANSERVICES;THE GOVERNMENT OF THE UNITED STATES OF AMERICA

发明人:

PASTAN, IRA,ONDA, MASANORI,NAGATA, SATOSHI,FITZGERALD, DAVID,KREITMAN, ROBERT,LEE, BYUNGKOOK

申请号：

ES06788523

公开号：

ES2372537T3

申请日:

2006.07.25

申请国别(地区):

ES

年份:

2012

代理人:

摘要：

An isolated Pseudomonas A ("PE") exotoxin A, in which said PE has a substitution with alanine, glycine, serine or glutamine instead of the amino acid residue R432, wherein the amino acid residue R432 is defined in reference to the amino acid sequence of the native PE (SEQ ID NO: 1).Una exotoxina A de Pseudomonas ("PE") aislada, en que dicha PE tiene una sustitución con alanina, glicina, serina o glutamina en lugar del resto aminoacídico R432, en que el resto aminoacídico R432 se define en referencia a la secuencia de aminoácidos de la PE nativa (SEQ ID NO:1).

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