PROBLEM TO BE SOLVED: To provide a suppository with a high therapeutic action, excellent in immobility, preserving property and quick dissolving property (collapsibility).SOLUTION: The suppository comprises following components (A)-(D). Wherein (A) is a fatty acid triglyceride solid at normal temperature, (B) is one or more 14-18C fatty acid glycerides solid at normal temperature, (C) is a base ingredient retaining in the lower region of rectum and (D) an ester oil which is a clear transparent liquid at normal temperature.COPYRIGHT: (C)2008,JPO&INPIT【課題】静止性、保管性および速溶性(崩壊性)の何れにも優れ、治療効果の高い坐剤を提供すること。【解決手段】次の成分(A)~(D)(A)常温で固体の脂肪酸トリグリセリド、(B)常温で固体の炭素原子数14から18のグリセリン脂肪酸エステルの1種または2種以上、(C)直腸下部滞留性基剤成分、(D)常温で澄明な液体のエステル油、を含有することを特徴とする坐剤。【選択図】なし