Monomethylvaline compounds having phenylalanine side-chain modifications at the C-terminus

• 收藏
• 分享

专利权人:

Inc.;Seattle Genetics

发明人:

Doronina, Svetlana O.,Kline, Toni Beth

申请号：

AU2006269422

公开号：

AU2006269422B2

申请日:

2006.07.07

申请国别(地区):

AU

年份:

2012

代理人:

摘要：

Auristatin peptide analogs of MeVal-Val-Dil-Dap-Phe (MMAF) are provided having C-terminal phenylalanine residue side chain replacements or modifications which are provided alone or attached to ligands through various linkers. The rlated conjugates can target specific cell types to provide therapeutic benefit.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/