Monomethylvaline compounds having phenylalanine side-chain replacements at the C-terminus

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专利权人:

Svetlana O. Doronina;Toni Beth Kline

发明人:

Svetlana O. Doronina,Toni Beth Kline

申请号：

US11994809

公开号：

US08343928B2

申请日:

2006.07.07

申请国别(地区):

US

年份:

2013

代理人:

摘要：

Auristatin peptide analogs of MeVal-Val-Dil-Dap-Phe (MMAF) are provided having C-terminal phenylalanine residue side chain replacements or modifications which are provided alone or attached to ligands through various linkers. The related conjugates can target specific cell types to provide therapeutic benefit.

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