v.v.i.;Ustav Organicke Chemie A Biochemie Akademie Ved Cr
发明人:
申请号：
EP14702744.5
公开号：
EP2945937B1
申请日:
2014.01.17
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
The invention provides helquat derivatives of general formula I, wherein substituents R1 and R2 are independently selected from a group comprising H and C1 to C3 alkyl； up to three of S1,2, S1&prime；,2&prime；, S3,4 and S3&prime；, 4&prime； are present, each of S1,2, S1&prime；,2&prime；, S3,4 and S3&prime；,4&prime； independently represents a linker consisting of a bivalent hydrocarbon chain having 3-6 carbon atoms； one or two atoms selected from the carbon atoms with the descriptor 2, 4, 2&prime；, and 4&prime； are substituted with a substituent R3 of general formula II or general formula III wherein R4 is substituted or unsubstituted aryl； T1 and T2 independently represent a bivalent hydrocarbon chain having 2-5 carbon atoms； and anions (X1)&minus； and (X2)&minus； independently represent anions of pharmaceutically acceptable salts. The helquat derivatives are useful as medicaments in the treatment of diseases related to increased cellular proliferation, such as oncologic diseases.
