CISEN PHARMACEUTICAL CO. LTD.;SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; CHINESE ACADEMY OF SCIENCES;SHANGHAI INSTITUTE OF MATERIA MEDICA
发明人:
YANG, CHUNHAO,MIAO, ZEHONG,DING, JIAN,WANG, MENG,HE, JINXUE,TAN, CUN,CHEN, YI
申请号：
EP13746724
公开号：
EP2813495A4
申请日:
2013.01.14
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
Provided in the present invention are a 2-arylbenzofuran-7-formamide compound as shown in general formula I or a pharmacologically or physiologically acceptable salt thereof, a preparation method thereof and use thereof in preparing anti-tumour drugs, wherein R 1 and R 2 are each independently hydrogen, straight or branched chained C 1 -C 4 alkyl, C 3 -C 4 cycloalkyl or saturated 5- or 6-membered heterocyclyl containing oxygen or nitrogen； or R 1 and R 2 together with N form an unsubstituted or substituted saturated 5- or 6-membered heterocyclyl containing at least one heteroatom, wherein the heteroatom is O, N and S, the substituent is a methyl on N； R 3 is a hydrogen atom or a chlorine atom； R 4 is a hydrogen atom or a fluorine atom； X is CH, CF or N； and Y is CH, CF or N.
