SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES;CISEN PHARMACEUTICAL CO., LTD.
发明人:
YANG, CHUNHAO,MIAO, ZEHONG,DING, JIAN,WANG, MENG,HE, JINXUE,TAN, CUN,CHEN, YI
申请号：
CA2863988
公开号：
CA2863988A1
申请日:
2013.01.14
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Provided in the present invention are a 2-arylbenzofuran-7-formamide compound as shown in general formula I or a pharmacologically or physiologically acceptable salt thereof, a preparation method thereof and use thereof in preparing anti-tumour drugs, wherein R1 and R2 are each independently hydrogen, straight or branched chained C1-C4 alkyl, C3-C4 cycloalkyl or saturated 5- or 6-membered heterocyclyl containing oxygen or nitrogen； or R1 and R2 together with N form an unsubstituted or substituted saturated 5- or 6-membered heterocyclyl containing at least one heteroatom, wherein the heteroatom is O, N and S, the substituent is a methyl on N； R3 is a hydrogen atom or a chlorine atom； R4 is a hydrogen atom or a fluorine atom； X is CH, CF or N； and Y is CH, CF or N.
