CHANG Shih-Ying,CHANG Shih-Ying,KIENTZLER Donald C.,KIENTZLER Donald C.,ERDEMIR Deniz,ERDEMIR Deniz,KIANG San,KIANG San,ROSENBAUM Tamar,ROSENBAUM Tamar
申请号：
SI201230878
公开号：
SI2793862T1
申请日:
2012.12.18
申请国别(地区):
SI
年份:
2017
代理人:
摘要：
A process for the production of a formulation of HIV attachment inhibitor piperazine tris salt prodrug compound involves dissolving the prodrug compound in a solvent to form a solution adding a first quantity of a first anti-solvent to the solution then dispersing a first quantity of HPMC in the solution adding a second quantity of the first anti-solvent to the solution dispersing a second quantity of HPMC in the solution then adding a second anti-solvent to the solution so as to crystallize the compound with the HPMC and thereby form the formulation, wherein the second anti-solvent is a combination of acetone and isopropyl acetate (IPAC). The formulation is then washed, and dried.
