SHIH-YING CHANG,DONALD C. KIENTZLER,DENIZ ERDEMIR,SAN KIANG,TAMAR ROSENBAUM
申请号：
PT12809969
公开号：
PT2793862T
申请日:
2012.12.18
申请国别(地区):
PT
年份:
2017
代理人:
摘要：
A process for the production of a formulation of HIV attachment inhibitor piperazine tris salt prodrug compound involves dissolving the prodrug compound in a solvent to form a solution adding a first quantity of a first anti-solvent to the solution then dispersing a first quantity of HPMC in the solution adding a second quantity of the first anti-solvent to the solution dispersing a second quantity of HPMC in the solution then adding a second anti-solvent to the solution so as to crystallize the compound with the HPMC and thereby form the formulation, wherein the second anti-solvent is a combination of acetone and isopropyl acetate (IPAC). The formulation is then washed, and dried.
