CHANG SHIH-YING,KIENTZLER DONALD C.,ERDEMIR DENIZ,KIANG SAN,ROSENBAUM TAMAR
申请号：
PL12809969
公开号：
PL2793862T3
申请日:
2012.12.18
申请国别(地区):
PL
年份:
2017
代理人:
摘要：
A process for the production of a formulation of HIV attachment inhibitor piperazine tris salt prodrug compound involves dissolving the prodrug compound in a solvent to form a solution； adding a first quantity of a first anti-solvent to the solution； then dispersing a first quantity of HPMC in the solution； adding a second quantity of the first anti-solvent to the solution； dispersing a second quantity of HPMC in the solution； then adding a second anti-solvent to the solution so as to crystallize the compound with the HPMC and thereby form the formulation, wherein the second anti-solvent is a combination of acetone and isopropyl acetate (IPAC). The formulation is then washed, and dried.
