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An Analogue of Epothilone, their use for the preparation of a Drug and a Pharmaceutical composition suitable for parenteral Administration.
专利权人:
BRISTOL-MYERS SQUIBB COMPANY
发明人:
ANDREA PANAGGIO,REBANTA BANDYOPADHYAY,TIMOTHY M. MALLOY,KRISHNASWAMY SRINIVAS RAGHAVAN,SAILESH AMILAL VARIA
申请号:
ARP140103915
公开号:
AR098109A2
申请日:
2014.10.17
申请国别(地区):
AR
年份:
2016
代理人:
摘要:
It is similar to cycloacetone represented by formula (1),And any solution or hydrate thereof for the treatment of patients requiring intravenous treatment and an effective amount of pharmaceutical ingredients, in which the ingredients in the drug preparation bottle are mixed, including The number of separate containers, similar degreased cyclophosphamide and solvents, therefore, when the components of these containers are mixed, the resulting solution ranges from 2 mg / ml to 4 mg / ml.The solvent consists of a mixture of equal volume of dehydrated ethanol and a suitable non ionized surface substance, expressed by formula (1).Dilute the resulting solution with an appropriate amount of diluent diluent such that the concentration of a similar diluent in the solution ranges from 0.1 mg / ml to 0.9 mg / ml.In the similar formula (1), the cycloacetone used to prepare the medicine and the medicine composition suitable for the parents' use. 3. Claim 3: cyclohexanone similar to that used in claim 1 or claim 2What's called "thinner" is whey ring spray Requirement 4: pharmaceutical ingredients suitable for parental management, characterized by a compound represented by formula (1) and its solution or hydrate; dehydrated alcohol; and an unborn surface. Claim 5: it is in conformity with the composition of claim 4, which is characterized in that the surface is risino oil of poly (Tetraene).Un análogo de epotilona, representado por la fórmula (1), y cualquier solvato o hidratos del mismo, que se usa en el tratamiento de un paciente que necesita un tratamiento mediante infusión intravenosa con una cantidad efectiva de una composición farmacéutica, en donde dicha composición farmacéutica se forma mezclando los contenidos de los frascos de una preparación farmacéutica que comprende, en frascos separados, un análogo de epotilona liofilizado y una cantidad de solvente para aquel de modo que cuando los contenidos de dichos frascos se combinan, la solución resultante contiene desde 2
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