METHODS OF CONJUGATING AN AGENT TO A THIOL MOIETY IN A PROTEIN THAT CONTAINS AT LEAST ONE SULFIDE BOND

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专利权人:

INC.;GENENTECH

发明人:

Jayme FRANKLIN,Xin Xin LIN,Jeffrey GORRELL,Timothy TULLY,Matthew HUTCHINSON,Charity Tucker BECHTEL

申请号：

US15414330

公开号：

US20170209593A1

申请日:

2017.01.24

申请国别(地区):

US

年份:

2017

代理人:

摘要：

The invention provides improved methods of conjugating an agent to a thiol moiety in a protein that contains at least one disulfide bond and at least one trisulfide bond. Exemplary embodiments include the production of antibody drug conjugates substantially free of impurities created in the presence of reactive sulfide moieties in the production processes.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/