METHODS FOR CONJUGATION OF AN AGENT WITH A THIOL COMPONENT IN A PROTEIN WHICH CONTAINS AT LEAST ONE TRISULPHIDE COMMUNICATION

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专利权人:

ДЖЕНЕНТЕК; ИНК. (US)

发明人:

ФРАНКЛИН Джейм (US),ЛИНЬ Синь Синь (US),ГОРРЕЛЛ Джеффри (US),ТАЛЛИ Тимоти (US),ХАТЧИНСОН Мэттью (US),БЕКТЭЛ Черити Такер (US)

申请号：

RU2017105428

公开号：

RU2017105428A

申请日:

2015.07.17

申请国别(地区):

RU

年份:

2018

代理人:

摘要：

The invention provides improved methods of conjugating an agent to a thiol moiety in a protein that contains at least one disulfide bond and at least one trisulfide bond. Exemplary embodiments include the production of antibody drug conjugates substantially free of impurities created in the presence of reactive sulfide moieties in the production processes.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/