LUXEMBOURG INSTITUTE OF SCIENCE AND TECHNOLOGY (LIST)
发明人:
CORNE, GAELLE,THOMANN, JEAN-SEBASTIEN
申请号：
CA3050036
公开号：
CA3050036A1
申请日:
2018.01.17
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The invention is directed to a method for manufacturing supported lipid bilayer on a porous silica nanoparticle with a ?-potential comprised between -10 mV and +10 mV, said method comprising the steps of (a) providing a negatively charged supported lipid bilayer on a porous silica nanoparticle, wherein said negatively charged supported lipid bilayer has a ?-potential inferior to -15 mV and wherein said negatively charged supported lipid bilayer comprised at least one phospholipid and； (b) adding a formulation of lipids, said lipids being 1,2-dioleoyl-3-trimethylammonium-propane alias DOTAP, cholesterol and at least one lipid different from DOTAP and cholesterol. Said method is remarkable in that it further comprises the step of (c) performing an ultra-sonication for promoting DOTAP incorporation. Said method can be supplemented by the step of addition of alginate and the step of cross-linking said alginate. The invention is also directed to nanocapsule and composition comprising said nanocapsule.
