Mhalla, Karim,Riguet, Eric,Campo, Brice,Gibelin, Antoine
申请号：
AU2007319000
公开号：
AU2007319000A8
申请日:
2007.11.09
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
The present invention provides novel compounds of formula (I) wherein W1, W2,W3, W4, W5, B, X1, X2, X3, X4, X5, E and L are as defined herein； invention compoundsare gamma amino butyrique acid receptor-subtype B ("GABAB") positiveallosteric modulators (enhancers), which are useful to provide methods of treatingor preventing diseases or disorders, including treatment of anxiety, depression,epilepsy, schizophrenia, cognitive disorders, spasticity and skeletal musclerigidity, spinal cord injury, multiple sclerosis, amyotrophic lateral sclerosis,cerebral palsy, neuropathic pain and craving associated with cocaine and nicotine,panic disorder, posttraumatic stress disorders, urge urinary incontinence,gastroesophageal reflux disease, transient lower oesophageal sphincter relaxations,functional gastrointestinal disorders and irritable bowel syndrome.
