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Triazinedione derivatives as GABAB receptor modulators
专利权人:
Karim Mhalla;Eric Riguet;Antoine Gibelin;Brice Campo
发明人:
Eric Riguet,Brice Campo,Antoine Gibelin,Karim Mhalla
申请号:
US12514241
公开号:
US08344138B2
申请日:
2007.11.09
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The present invention provides novel compounds of formula I wherein W1, W2, W3, W4, W5, B, X1, X2, X3, X4, X5, E and L are as defined herein; invention compounds are gamma amino butyrique acid receptor-subtype B (“GABAB”) positive allosteric modulators (enhancers), which are useful to provide methods of treating or preventing diseases or disorders, including treatment of anxiety, depression, epilepsy, schizophrenia, cognitive disorders, spasticity and skeletal muscle rigidity, spinal cord injury, multiple sclerosis, amyotrophic lateral sclerosis, cerebral palsy, neuropathic pain and craving associated with cocaine and nicotine, panic disorder, posttraumatic stress disorders, urge urinary incontinence, gastroesophageal reflux disease, transient lower oesophageal sphincter relaxations, functional gastrointestinal disorders and irritable bowel syndrome.
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