DORSEY BRUCE D.,LEARN KEITH S.,MORRIS EMMA L.,OTT GREGORY R.,ROFFEY JONATHAN R.,SOUDY CHRISTELLE N.,WAGNER JASON C.
申请号：
NZ62544712
公开号：
NZ625447A
申请日:
2012.11.19
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
The present disclosure provides a compound of formula (I) or a salt thereof, wherein R1, R2, R3, R4, R5, R6, A, G, M, Q and X are as defined herein. A compound of formula (I) and its salts have a PKC inhibitory activity, and may be used to treat proliferative disorders such as cancer. Examples of compounds of formula (I) are: (S)-3-Phenyl-N*1*-(2-pyridin-4-yl-7-[1,2,3]triazol-1-yl-thieno[3,2-d]pyrimidin-4-yl)-propane-1,2-diamine； (S)-N*1*-[7-(2-Cyclopropyl-ethyl)-2-pyridin-4-yl-thieno[3,2-d]pyrimidin-4-yl]-3-phenyl-propane-1,2-diamine； (E)-3-[4-((S)-2-Amino-3-phenyl-propylamino )-2-pyridin-4-yl-thieno[3,2-d]pyrimidin-7-yl]-acrylic acid tert-butyl ester and 4-((S)-2-Amino-3-phenyl-propylamino)-2-pyridin-4-yl-thieno[3,2-d]pyrimidine-7-carboxylic acid dimethyl amide.
