The disclosure relates to certain benzofuropyrimidinone compounds to formula (I) and pharmaceutically acceptable salts thereof wherein the variables R1, R2, R3a, R3b, R3c and R3d are as defined in the specification, pharmaceutical compositions thereof, and methods of use thereof. These compounds are useful for inhibiting protein kinases such as PIM (PIM-1, PIM-2 and/or PIM-3), CDC7 or CK2 in a cell, thereby making them suitable for treating a cancer selected from pancreatic cancer, prostate cancer, hepatocellular carcinoma, lymphomas, leukemias, colorectal in a patient.
