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METHOD FOR PREPARING TABLETS CONTAINING 5-HYDROXYTRIPTOPHANE AND TRIPTOPHANE
专利权人:
АМБРОС ФАРМА С.Р.Л. (IT)
发明人:
СТАНКОВ Божидар Михайлов (IT)
申请号:
RU2012131144/15
公开号:
RU2012131144A
申请日:
2010.12.23
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A method of preparing a two-layer tablet in which one fast layer contains 5-hydroxytryptophan (5-HTP) and the other deposited layer contains tryptophan (Trp) or 5-hydroxytryptophan (5-HTP), the method comprising the following stages: 1) preparation of the mixture for the “quick” layer using the following intermediate steps: i) granulation of the mixture of the following ingredients: the first part of microcrystalline cellulose, the first part of croscarmellose sodium, 5-hydroxytryptophan (5-HTP), hydroxypropylmethyl cellulose and granulating dye a solution containing deionized water and polyvinylpyrrolidone; ii) granule calibration; iii) drying the calibrated granules in a vacuum chamber at 45 ° C so that the liquid content in the granules becomes less than 1%; iv) sieving the dried granules through a sieve with a hole diameter of approximately 2 mm ; v) adding to the sieved granules the remaining portion of croscarmellose sodium, sodium stearate dicalcium phosphate and polyvinylpyrrolidone sieved through a porous filter with a pore diameter of approximately 0.7 mm; vi) stirring the product is intermediate of step v); 2) preparation of the “deferred” layer mixture using the following intermediate steps: a) mixing one ingredient from tryptophan and 5-hydroxytryptophan with dicalcium phosphate; b) granulating the mixture for the intermediate step a) using a granulating solution containing deionized water and polyvinylpyrrolidone; c) calibration of the granules of the intermediate step b) and drying in a vacuum chamber at 45 ° C, so that the liquid content in the granules becomes less than 1%; d) intermediate to the pre-calibrated product1. Способ приготовления двухслойной таблетки, в которой один слой «быстрый» содержит 5-гидрокситриптофан (5-НТР), а другой слой «отложенный» содержит триптофан (Trp) или 5-гидрокситриптофан (5-НТР), причем упомянутый способ содержит следующие этапы:1) приготовление смеси для «быстрого» слоя с помощью следующих промежуточных этапов:i
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